Evaluation of serum vitamin D and its correlation with total antioxidant capacity (TAC) in patients with polycystic ovary syndrome (PCOS)

Background: There is few evidence about antioxidants properties of vitamin D. Recent studies suggest that oxidative stress may play a major role in the pathophysiology of polycystic ovary syndrome (PCOS). The aim of this study was to evaluate the correlation between serum 25-hydroxy vitamin D (25-OH-D) and total antioxidant capacity (TAC) in PCOS group compared to control group.Methods: This case-control study was done on 60 women with PCOS and 90 healthy women as control group. All women were 20-40 years old who referred to Fatimah Zahra Infertility and Reproductive Health Research center, Babol, Iran. This study was approved by the Ethics Committee of Babol University of Medical Sciences. The control and patient groups were matched by age, weight, BMI and PCOS was diagnosed according to the Rotterdam criteria (2003). Serum levels of (25-OH-D) and TAC were measured using ELISA and FRAP methods respectively. Correlations between vitamin D and TAC were evaluated by spearman correlation test in both group.Result: It was found that the mean of serum (25- OH- D) was lower in PCOS group (10.76 ± 4.17) than control group (12.07 ± 6.26), but this difference was not statistically significant (P = 0.125). TAC was significantly lower in PCOS group compared to control group (P= 0.002). No significant correlation was found between serums (25- OH- D) and TAC in both groups.Conclusion: The findings indicated no significant differences in the serum vitamin D levels between PCOS patients and matched controls, also no correlation was observed between the serum vitamin D levels and total antioxidant capacity.

Keywords:

Oxidative stress , Total antioxidant capacity , Vitamin D , Polycystic ovary syndrome