Comparative evaluation of Notch signaling pathway in the endometrium of women with PCOS, endometriosis, RIF and healthy fertile controls during the window of implantation

Background: Notch signaling pathway is best known for their role in cell fate, cell survival, cell differentiation and death during embryonic and adult development. Based on recent researches, it is important for endometrial remodeling, decidualization and implantation in mice.Methods: To investigate potential roles of the Notch signaling family in human endometrium during the window of implantation, we examined the expression levels of Notch receptors (NOTCH1,2,3), Notch ligands (Jag1,2) and survivin as a downstream target gene of Notch signaling in mid secretory phase of menstrual cycle in endometrial biopsies taken from healthy women, PCOS, endometriosis and repeated implantation failure patients (n=10 per each group) by QRT-PCR.Result: All the endometrial samples expressed Notch1, 2, 3, Jagged1, 2 and survivin. There were significant differences (pConclusion: It seems that dysregulation of Notch pathway may be one of the causes of the reduced endometrial receptivity.

Keywords:

Endometriosis , Luteal phase , PCOS , Repeated implantation failure , Endometriun