Effects of Parsley Aqueous Extract on Ovarian Histological Changes in Polycystic Ovary Syndrome Rat Model

Backgournd: Polycystic ovary syndrome (pcos)is one of the most common endocrine disorders in the reproductive age female around the world. Chronic low-grade inflammation has been suggested to play an important role in the pathogenesis and development of this syndrome. Regarding the antioxidant and anti-inflammatoryproperties of parsley, this study was conducted to determine the effect of parsley on morphology of ovarian tissue in pcos rat model. Methods: In this study the syndrome induced by muscular injection of 40 mg/kg Estradiol Valerate to 32 female Wistar rats, weighing 170-180 g. After 60 days the animal divided to control, pcos and pcos treated with Parsley (1000 and 2000 mg / kg by gavage for 21 days). At the end of study, the rat ovaries were evaluated histologically. Results and Discussion: Histological studiesshowed significant increases in the number of primordial, primary, pre-antral and cystic follicles in comparison with the control group (P < 0.05). Measurement ofgranulosa, Theca, number and diameter of different cysts and follicles showed significant improvement in polycystic ovary in rats treated with parsley. Conclusion: These findings indicate that parsly have a protective effects on polycystic ovary syndrome maybe due to its antioxidant and antiinflammatory properties

Keywords:

Polycystic syndrome ovary , Parsley , Ovary