SYNTHESIS OF 1,4-DIHYDROPYRIDINE BY CATALYZED SBA-15 VIA THE HANTZSCH REACTION UNDER SOLVENT FREE CONDITIONS

The purpose of this research is the synthesis of meso structured silica or Santa Barbara Amorphous (SBA-15) as a green Nano catalyst witch, is used in the Hantzsh synthesis (synthesis of 1,4-dihydropyridine derivatives). The reaction was performed under solvent free condition in a short time and the products were obtained in high yield and purity. Due to the chemical and pharmaceutical applications of these compounds, this work presents a new approach for the synthesis of 1,4-dihydropyridine compounds. The catalyst was separated easily by simple filtration of the residual and it is reused several times without decreasing the activity.

Keywords:

SBA-15 , Hantzsh reaction , 1 , 4–dihydropyridine , green Nano catalyst