Spherical Bioactive Glass Nanoparticles for Bone Regeneration

Bioactive glass (BG) nanoparticles have the potential to be injected directly into the defect site to allow healing and regeneration of bone tissue. In this study 80S20C (80 mol% SiO2 and 20 mol% CaO) BG nanoparticles, with controlled particle size (150-400nm), have been synthesised and characterized. The bioactivity of 80S20C nanoparticles was investigated in simulated body fluid over various time points and the formation of hydroxy apatite layer was analysed using a range of techniques. The cellular response of these nanoparticles to human mesenchymal stem cell (hMSC) was assessed. MSCs were found to uptake the nanoparticles and the particles were shown to be not cytotoxic and did not inhibit cellular activity.

Keywords:

Nanomaterial , Bioactivity , Tissue Regeneration , Nanomedicine , Nanotoxicity