Multi-Component Reactions for the Synthesis of Arylsulfonyl hydrazide Derivatives

Most of the biologically active compounds include sulfonamides, and they are an importantclass of drugs showing various activities such as antimicrobial, antitumor, anticonvulsant, anticancer,anti-inflammatory, antidiuretic, antihydrod, insulin-releasing and hypoglycemic.They also act as inhibitors, e.g., histone deacetylase (HDAC), carbonic anhydrase and HIVprotease. The chemotherapeutic derivatives of this class are extensively employed as antibacterialand antiviral agents. Since, they are structural analogues of p-aminobenzoic acid necessaryfor the production of folic acid. If they are substituted for p-aminobenzoic acid, the productionof folic acid stops and ultimately bacterial growth stops. Sulfonyl hydrazones exhibitinteresting chemical properties and are useful intermediates in organic synthesis.