Synthesis of 2-Amino-5-hydroxy Pyrimidines as the Novel Analogues of Tyrosinase Substrate

Tyrosinase is an oxidoreductase enzyme which catalyzes o-hydroxylation of monophenolsinto their corresponding o-diphenols. It also oxidizes o-diphenols to the corresponding oquinonesusing molecular oxygen. Due to the high chemical activity, o-quinones participate infurther chemical reactions and form macromolecules known as melanin which are the coresubstances of natural pigment of skin, eyes, and hair [1]. The synthesis of o-diphenols is a potentiallyvaluable catalytic ability and thus tyrosinase has attracted a lot of attention with respectto industrial applications. Various dermatological disorders, such as melanoma, agespots, and sites of actinic damage arise from the accumulation of an excessive level of epidermalpigmentation originated from hyper activity of tyrosinase. In addition, unfavorableenzymatic browning of plant-derived phenolic compounds by tyrosinase causes a decrease innutritional quality and economic loss of food products [2]. Consequently, a great deal of researchhas been directed toward finding compounds that can inhibit tyrosinase activities.Based on the scientific literature in this field, some 5-hydroxy pyrimidine derivatives weredesigned to work as analogues of tyrosinase substrates.