In the present work, the effects of inorganic oxide nanoparticles on the removing efficiency of polybuthylene terephthalate-based nanocomposites were extensively studied. Four sorbent based on
polybuthylene terephthalate nanocomposites containing different types of nanoparticles along with a pristine polybuthylene terephthalate polymer were conveniently electrospun on counter electrode. The applicability of nanocomposites was examined by removing fluoxetine, as model compounds, from aqueous samples. Subsequently, the removing analyte was transferred into a gas chromatography by thermal desorption. Parameters affecting the morphology and capability of the prepared nanocomposites including the type of nanoparticles and their doping levels along with the coating time were optimized. Four types of nanoparticles including Fe3O4, SiO2, CoO and NiO were examined as the doping agents and among them the presence of SiO2 in the prepared nanocomposite was prominent. The homogeneity and the porous surface structure of the SiO2-polybuthylene terephthalate nanocomposite were confirmed by scanning electron microscopy indicating that the nanofibers diameters were lower than 300 nm. In addition, important parameters influencing the removing and isolation process such as temperature time, ionic strength and removing solvent were optimized. Eventually, the developed method was validated by gas chromatography–mass spectrometry. Under optimized conditions, GC-MS analyses of the eluting solvent indicated that initial total
fluoxetine was removing and transferring in methanol phase. methanol was reported as a good extractant solvent. The whole procedure proved to be conveniently rapid, efficient and economical to removing of
fluoxetine from environmental and biological samples. Eventually, the developed method was applied to the analysis of water, urine, milk and plasma samples and removing recoveries of 85 to 98% were achieved.