Effect of 6-Gingerol on VLDL Lipoprotein: Molecular Docking Investigation

The purpose of this study was to evaluate the effect of 6-gingerol, the most abundant ingredient in ginger extract, on reducing VLDL (very low-density lipoprotein) in the blood stream. Molecular docking technique was performed to investigate the probable interactions. B3lyp/6-31g method was used to determine docking data. The results confirm that 6-gingerol was docked into the catalytic site of VLDL. The mean binding energy value of the lowest docking energy conformations of 6-gingerol to the active site of VLDL was obtained to be about -8.8 Kcal/mol

Keywords:

Ginger , 6-Gingerol , VLDL , Molecular docking