Chemoselective Reaction of Aaldehydes and 2-Methyl-5-pyrazolone in Different Basic and Acidic Choline chloride-based Deep Eutectic Solvents
Publish place: 27th Iranian Seminar on Organic Chemistry
Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
ISOC27_065
تاریخ نمایه سازی: 19 اسفند 1399
Abstract:
Solvents play a key-role for the development of more efficient chemical transformations and industrial processes. A new generation of solvents, named Deep Eutectic Solvents (DESs), was presented as suitable alternative solvents compared to conventional and unconventional solvents, such as ionic liquids (ILs).1,2 Pyrazoles are an important class of bio-active drug targets in the pharmaceutical industry, as they are the core structure of numerous biologically active compounds.3 In this work, the chemoselectivity of the reaction of aromatic aldehydes and 2-methyl-5-pyrazolone, as active methylene compound, for the tandem synthesis of bis(pyrazolyl)methanes 1 and dipyrazolopyrane hybrids 2 in different basic and acidic Choline chloride-based deep eutectic solvents (DESs) has been investigated (Figure 1).
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Authors
Adeleh Moshtaghi Zonouz
Chemistry Department, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran
Akbar Saiyar
Chemistry Department, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran