Synthesis of uric acid with phosphorus acid tags as a novel biological-based organocatalyst: Its application for synthesis of N-heterocycle
Publish place: 27th Iranian Seminar on Organic Chemistry
Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
ISOC27_270
تاریخ نمایه سازی: 19 اسفند 1399
Abstract:
Task-specific development of chemical methodologies for synthesis of target molecules may be achieved via rational design, applying a suitable procedure and reactants 1. Heterocyclic moieties had been used as important building blocks within a wide range of medicinal and biological active molecules 2. Among of oxygen and nitrogen hetreocycles, the N-amino-2-pyridones and pyrano [2,3-c]pyrazoles, had been shown, anticancer, anticoagulant, anticonvulsant, antimicrobial, anti-HIV, antimalarial, anti-tumor, antibacterial, antifungal and antitumor properties 3. Biological-based uric acid with phosphorus acid tags (UAPA) as an efficient catalyst was successfully used for the synthesis of N-heterocycle via a multi-component reactions (MCRs) of various aromatic aldehyde, ethyl cyanoacetate and hydrazine under solvent free condensation (Scheme 1).
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Authors
Sima kalhor
Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali-Sina University, Hamedan, ۶۵۱۷۸۳۸۶۸۳, Iran
Hassan Sepehrmansourie,
Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali-Sina University, Hamedan, ۶۵۱۷۸۳۸۶۸۳, Iran
Mahmoud Zarei
Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali-Sina University, Hamedan, ۶۵۱۷۸۳۸۶۸۳, Iran
Mohmmad Ali Zolfigol
Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali-Sina University, Hamedan, ۶۵۱۷۸۳۸۶۸۳, Iran