Novel methodologies for the synthesis of indole derived scaffolds
Publish place: 27th Iranian Seminar on Organic Chemistry
Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
ISOC27_296
تاریخ نمایه سازی: 19 اسفند 1399
Abstract:
Indole derivatives are very important heterocyclic compounds in the drug-discovery studies. They represent a very important class of molecules that play a major role in cell biology and are potential naturally occurring products. There has been an increasing interest in the use of indole derivatives as bioactive molecules against microbes, cancer cells, and various kinds of disorder in the human body.1 In this case, indole often considered to be the pre-eminent heterocycle and this molecular scaffold has the greatest medicinal importance that attracted the attention of chemists and biologists.2 In this presentation, we attempt to present new methodologies for the synthesis of indole, isoindole, benzoindole, fused Indoles, bis-indole, bis(indolyl)methanes, spiroindole, spirooxindole, indoloindole and also presented strategies for synthetic modification of indole via C2 functionalization, C3 functionalization and N functionalization of indoles (Figure 1). These new methods have been fragmented across the literature of organic chemistry.
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Authors
Shima Nasri,
Department of Chemistry, Faculty of Science, Imam Khomeini International University, Qazvin, Iran
Mohammad Bayat
Department of Chemistry, Faculty of Science, Imam Khomeini International University, Qazvin, Iran