One pot synthesis of some new 2-((4-methylphenyl) sulfonamido)benzamide derivatives

Multi component reactions are one of the most effective procedures for economical synthesis of structural diversity and molecular complexity in a simple process1. Sulfonamides as chemotherapeutic agents are known almost one hundred years. Recently, there has been increasing attachment to sulfonamides in connection with development of the application of these compounds that can interact with various targets2. The existence of donor and acceptor atoms in sulfonamide helps them to participate in the system of different hydrogen bond networks3. In this work, we wish to report synthesis of some new 2-((4-methylphenyl) sulfonamido) benzamide derivatives 4 by reaction of 2-aminobenzamide derivatives 1, 1,3-diketon 2 and p-toluenesulfonic acid 3 in the absence of reagents.

Keywords:

Multi component reactions , Sulfonamide , 2-Aminobenzamide , 1 , 3-diketon