Synthesis of 4,4'-(aryl methylene)bis(3- methyl-1H-pyrazol-5-ol)s
Publish place: 27th Iranian Seminar on Organic Chemistry
Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
ISOC27_354
تاریخ نمایه سازی: 19 اسفند 1399
Abstract:
Fe3O4 @ SiO2@APTES@CC@ DEA @Cu as a new green and recyclable solid catalyst was prepared. Green chemistry has led to the use of nano-magnetic catalysts, which are considered as heterogeneous catalysts in many of the multi-component reactions due to its high activity, easy separation and reuse. Magnetic nanoparticles are easily prepared and separated from the reaction medium by external magnetism, so the catalyst based on Fe3O4 nanoparticles can easily be removed from the reaction and reused. The catalytic activity of Fe3O4 @ SiO2 @APTES @CC@ DEA @Cu was evaluated for synthesis of 4,4'-(aryl methylene)bis(3- methyl-1H-pyrazol-5-ol)s via one-pot reactions of phenylhydrazine/or hydrazine hydrate, ethylacetoacetate and aldehydes under solvent-free condition. 4,4′-(Aryl methylene) bis(1H-pyrazol-5-ol)s as an important class of heterocyclic compounds have been exhibited a wide range of biological activities such as antimalarial1, antifungal2, anti-inflammatory3 , antimicrobial. Also, they are used as important intermediates in organic synthesis.
Keywords:
Authors
Amir ghanbarpur
Department of Organic Chemistry, Faculty of Chemistry, bu ali sina University, Hamedan, Iran
Ardeshir khazaei
Department of Organic Chemistry, Faculty of Chemistry, bu ali sina University, Hamedan, Iran
Maryam mahmudiani
Department of Organic Chemistry, Faculty of Chemistry, bu ali sina University, Hamedan, Iran