Multicomponent reaction for synthesis of dihydropyrroles

Multicomponent reactions (MCRs) have become useful tools for diversity-oriented and complexity-generating synthesis of natural products and drug-like small molecules with novel properties.1 Heterocyclic molecules are ubiquitous,s structural motifs in a wide range of biologically relevant molecules and natural products. Developing methods for rapid and efficient synthesis of structurally diverse heterocyclic molecules represents one of the major domains in both synthetic chemistry and drug discovery. In this context, dihydropyrrole represents one of the most important structural motifs presenting in biologically active molecules.2 Herein one-pot synthesis of 2,5-dihydropyrrole-dihydropyrrole contain sultam carried out with good yield and cost-effective starting materials. In this regard at the first saccharin was used as acid in Ugi multicomponent reaction (after α-amino amide formed) sodium azide was added as nucleophile and 3-dihydropyrroles contain sultam (6a-l) synthesized. High atom economy, good yield and stereoselectivity is benefits of this procedure. The details about the synthesis will be further discussed in the conference (Fig. 1).

Keywords:

Multicomponent reactions , Isocyanides , 2 , 5-dihydropyrrole-dihydropyrrole , Sultam.