Synthesis, characterization and antitumor activity of new Cu(II) mixed ligand coordination polymers at bulk-size and nanopowders

New cupper(II) mixed ligand coordination polymer at bulk and nanopowders [Cu3(μ3-BTCA)2(Pyr)3.3(H2O)]n [BDCA = Benzene 1,3,5-tree carboxylic acid and Pyr = Pyridine], has been synthesized by the reaction of a mixture Cu(II) acetate and BDCA in pyridine/water by simple branched tube and sonochemical method. The nanopowders of CuO was prepared from the calcinations of the NCP at air atmosphere. The structure of the CP and NCP (CP = Coordination polymers and NCP = Nano coordination polymers) were determined by X-ray crystallography, while nano-structural materials were characterized by X-ray powder diffraction (XRPD), thermal gravimetric analysis (TGA) and scanning electron microscopy (SEM). These binary complexes (CP and NCP) were tested in vitro as potential antitumor agents with Human Embryonic Kidney 293 cells. It was observed that the most stable NCP and CuO nanopowders exhibited a high antitumor activity respectively.

Keywords:

Coordination polymer , Nanopowders , Antitumor activity