Fabrication and Properties of Collagen and Polyurethane Polymeric Nanofibers Using Electrospinning Technique for Tissue Engineering Applications

The present study introduces a nanofibers skin patch comprised of collagen and polyurethane polymers. Belonging to the family of biodegradable polymers, they can be mixed with various drugs, degraded at the wounded area, whereby the drug is gradually released into the wound. The characterization of nanofibers were identified using mechanisms such as SEM, FTIR, and tensile test. The results of SEM analysis indicated that all the fabricated nanofibers have a proper and uniform morphology. FTIR spectrum for collagen and TPU revealed various factor groups including N-H group with hydrogen bond, CH۲ group, (C=O) carbonyl group, and carboxyl group (COO) for collagen. Furthermore TPU spectrum demonstrated a broad peak for N-H group, the symmetric and asymmetric stretching for CH۲ group as well as carbonyl group (C=O) peak. In addition, a tensile test examined the mechanical properties of nanofibers with and without loaded natural honey, indicating that the use of natural honey in the structure of nanofibers decreases the maximum stress at break point.

Keywords:

Nanofiber , Electrospinning , Scaffold , Tissue engineering , Chitosan , Polyurethane