Effect of gallic acid on cognitive impairments in the cerebral ischemia/reperfusion animal model

Occlusion of the middle cerebral artery is the most common reason of ischemic stroke that can lead to a reduced cognitive performance. Gallic acid (GA) has been studied against diseases associated with damage caused by oxidative stress due to its high antioxidant capacity. The present study aims to evaluate the impact of GA on cognitive disorders in the animal model of cerebral ischemia-reperfusion (I/R). In this study, the rats divided into four groups: control, ischemia, ischemia pre-treatment with (۲۵, ۵۰ mg/kg) GA. Bilateral common carotid artery occlusion (BCCAO) was inducted to the ischemia group through a surgery. Animals in pre-treatment group received Gallic Acid for ۳۰ days. The novel object test was carried out three days after the induction of ischemia. The results showed that I/R induction had caused a reduction in the discrimination index of the novel object test (P <۰.۰۰۱). Treatment with ۵۰GA caused a significant increase in the discrimination index comparison with I/R group (P < ۰.۰۵). The antioxidant property of Gallic acid maybe plays a role in improving the discrimination index and learning disorders. Accordingly, using this substance might prove to be efficient in the treatment of cognitive disorders from a stroke.

Keywords:

Antioxidant , Oxidative stress , novel object test , learning