The cost-effective synthesis of antiviral drug Acyclovir in high yield and purity
Publish Year: 1400
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
ICCNRT04_050
تاریخ نمایه سازی: 20 مهر 1400
Abstract:
Due to the special importance of the synthesis of antiviral drugs, in the present study we described a high yield procedure for the industrially production of Acyclovir as a selective anti-herpes agent. In this study acyclovir was synthesized from di-Acetyl acyclovir trough mild hydrolysis process. The structure of synthesized sample were confirmed by their NMR chemical shifts (۱H-NMR and ۱۳C-NMR) and high-performance liquid chromatography HPLC data. This procedure represented an acceptable yield about ۷۰% (based on di-Acetyl acyclovir weight) with more than ۹۸.۷% purity of Acyclovir
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Authors
Adileh Ayati
Antibiotic Sazi Iran Company (ASICO) ۵th Km of Khazarabbad Road- Sari-IRAN
Marzieh Sadatshahabi
Antibiotic Sazi Iran Company (ASICO) ۵th Km of Khazarabbad Road- Sari-IRAN
Maryam Molkara
Antibiotic Sazi Iran Company (ASICO) ۵th Km of Khazarabbad Road- Sari-IRAN
Nader Teymoori
Antibiotic Sazi Iran Company (ASICO) ۵th Km of Khazarabbad Road- Sari-IRAN