Publisher of Iranian Journals and Conference Proceedings

Please waite ..
Publisher of Iranian Journals and Conference Proceedings
Login |Register |Help |عضویت کتابخانه ها
Paper
Title

Transcriptomic analysis of MCF-۷ cells treated in acidosis

Year: 1400
COI: ICSB04_059
Language: EnglishView: 92
متن کامل این Paper منتشر نشده است و فقط به صورت چکیده یا چکیده مبسوط در پایگاه موجود می باشد.
توضیح: معمولا کلیه مقالاتی که کمتر از ۵ صفحه باشند در پایگاه سیویلیکا اصل Paper (فول تکست) محسوب نمی شوند و فقط کاربران عضو بدون کسر اعتبار می توانند فایل آنها را دریافت نمایند.

Buy and Download

متن کامل (فول تکست) این مقاله منتشر نشده و یا در سایت موجود نیست و امکان خرید آن فراهم نمی باشد.

Authors

Iliya Rafiei - Research Institute for Fundamental Sciences (RIFS), University of Tabriz, Tabriz, Iran
Mehdi Damaghi - Department of Cancer Physiology, Moffitt Cancer Center and Research Institute, Tampa, Florida ۳۳۶۱۲, USA. Department of Oncologic Sciences, Morsani College of Medicine, University of South Florida, Florida, USA
Behzad Nikzad - Research Institute for Fundamental Sciences (RIFS), University of Tabriz, Tabriz, Iran
Mehdi Sadeghi - Department of Cell and Molecular Biology, Faculty of Science, Semnan University, Semnan, Iran

Abstract:

The cancer microenvironment becomes highly acidic in the early stages of cancer. This phenomenon is caused due to poor vascular perfusion, hypoxia and fermentative glycolysis(۱). Cancer cells need to adapt to this environment to survive. When a tumour starts to form most of these pre-malignant cells are avascular. Thereby, they tend to switch to a more glycolytic metabolism to provide sufficient energy for these cells to thrive. This metabolic shift causes the cells microenvironment to become highly acidic due to the production of organic acids. This metabolic shift becomes hardwired to these malignant cells as Warburg stated previously which leads to the continuous production of organic metabolic acids and hence a highly acidic microenvironment. However, the underlying mechanisms causing these cells to adapt to this niche while the microenvironment becomes toxic to other normal cells is not properly understood. Thereby, further research in this area could lead to great discoveries regarding how cancerous cells evolve, survive and thrive. Multiple scientific literature has been published in this field of research however, a unique method of cell culture and a thorough analysis at a systems level seems to tackle the issue properly(۲).

Keywords:

Paper COI Code

This Paper COI Code is ICSB04_059. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1290924/

How to Cite to This Paper:

If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Rafiei, Iliya and Damaghi, Mehdi and Nikzad, Behzad and Sadeghi, Mehdi,1400,Transcriptomic analysis of MCF-۷ cells treated in acidosis,The 4th Iranian Conference on Systems Biology,Tehran,https://civilica.com/doc/1290924

Research Info Management

Certificate | Report | من نویسنده این مقاله هستم

اطلاعات استنادی این Paper را به نرم افزارهای مدیریت اطلاعات علمی و استنادی ارسال نمایید و در تحقیقات خود از آن استفاده نمایید.

Scientometrics

The specifications of the publisher center of this Paper are as follows:
Type of center: دانشگاه دولتی
Paper count: 23,829
In the scientometrics section of CIVILICA, you can see the scientific ranking of the Iranian academic and research centers based on the statistics of indexed articles.

New Papers

Share this page

More information about COI

COI stands for "CIVILICA Object Identifier". COI is the unique code assigned to articles of Iranian conferences and journals when indexing on the CIVILICA citation database.

The COI is the national code of documents indexed in CIVILICA and is a unique and permanent code. it can always be cited and tracked and assumed as registration confirmation ID.

Support