Efficient one-pot synthesis of 1-[-2-(alkylimino)-4-methyl-3-phenyl- 2,3-dihydrothiazole-5-yl]-ethanone from the reaction of phenyl iso thiocyanate , primary amines, and 3-chloroacetylacetone

In this article a new and efficient method for the preparation of 1-[-2-(alkylimino)-4-methyl-3-phenyl-2,3- dihydrothiazole-5-yl]-ethanone from the reaction of primary amines and phenylisithiocyanatein the presence of 3-chloroacetylacetone is presented.This new protocol has several advantages such as high yields, simple experimental and work-up, and reaction is performed at room temperature under neutral condition by mixing of the starting materials.

Keywords:

2 , 3-dihydrothiazoles , 3-chloroacetylacetone , phenylisothiocyanate , primary amines