Synthesis of ۲-substituted benzoxazoles by hydrophobic ethyl-bridged periodic mesoporous organosilica functionalized sulfonic acid
Publish Year: 1400
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
SDNCONF06_047
تاریخ نمایه سازی: 2 بهمن 1400
Abstract:
A series of metal-free tandem reactions for the synthesis of pharmaceutical and industrial ۲-substituted benzoxazoles from isothiocyanates with ۲-aminophenol in the presence of Et-PMO-Me-PrSO۳H (۱b) as a solid acid were carried out efficiently and selectively in solvent free condition. A significant selectivity toward ۲-mercaptobenzoxazole derivatives due to hydrophobic nature of the solid catalyst was observed. Simple experimental procedure with novel selective approach toward benzoxazoles accompanied by green and reusable catalyst could be considered as an alternative feature of this protocol to the existing methods for the synthesis of ۲-substituted benzoxazoles derivatives.
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Authors
Akbar Mobaraki
Department of Chemistry, Kharazmi University, ۴۹ Mofateh St., Tehran ۱۵۷۱۹-۱۴۹۱۱, Iran.
Babak Karimi
Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan ۴۵۱۳۷-۶۷۳۱,Iran.
Hamid M. Mirzaei
Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan ۴۵۱۳۷-۶۷۳۱, Iran.