۱th National Congress on Recent Novel approaches in system biology Catalase as an Antioxidant Enzyme Therapeutic for COVID-۱۹

The severe acute respiratory syndrome coronavirus ۲ (SARS-CoV-۲) caused the COVID-۱۹ outbreak in Wuhan, China in December ۲۰۱۹. Recent studies prove that oxidative stress is an essential factor that increases the severity of COVID-۱۹ in patients (۱). The antioxidant defense system including CAT, GPx, GSR, and SOD, increases the levels of reduced glutathione, and suppresses the expression of NADPH oxidase, thereby contributing to reducing oxidative stress and cellular oxidation. The Catalase enzyme consists of ۴ subunits, each of these subunits is ۶۰ kDa, and its molecular mass is ۲۴۰ kDa. In animals, hydrogen peroxide is destroyed by CAT and GPX. Reduction of catalase activity in Patients with Covid-۱۹ leads to the enhancement of H۲O۲ (۲). Fig ۱. structure of SARS-CoV-۲. The viral structure is primarily formed by the structural proteins such as spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins. The S, M, and E proteins are all embedded in the viral envelope, a lipid bilayer derived from the host cell membrane. The N protein interacts with the viral RNA in to the core of the virion

Keywords:

COVID-۱۹ , Catalase , Antioxidant system.