correlation between BP۱ and SPL۱ and protein phosphorylation in spms(multiple sclerosis)

Introduction: MS, as a chronic autoimmune disease with unknown etiology, is the most commonneurological disorder in young adults. It is characterized by the infiltration of auto-reactive immune cells intothe central nervous system (CNS), which leads to inflammation, demyelination, and axonal degeneration.Several studies suggest that genetic, environmental, epigenetic and infectious factors may contribute to theetiology and pathogenesis of MS. This essay survey death ratio reason of SPMS patient.Material and method: In order to start this study, we used GEO accession number GSE۱۳۱۲۸۲. In our work,we focus on patient with less disease duration, then by the use of GEO۲R web tool, we analyzed theinformation. Eventually, for every gene list we removed differentially expressed genes (DEGs) which had pvaluemore than ۰.۰۵ and log ۲ FC between ±۰.۶. protein-protein interaction (PPI) was used to find theproteins that is coded by DEGs, thereby string data base was utilized for this aim. The list of DEGs wasdeposited in this data base and output, PPI network, was received. To analyze PPI networks, Cytoscape ۳.۴.۰and Gephi software v ۰.۹.۱ were used to visualization of networks.Result: samples of patients and controls were compared to identify DEGs in each disease. The number ofDEGs were ۸۰۱ genes in SPMS which ۳۵۶ were upregulated and ۴۸۴ were downregulated. Analysis ofmodules and their functional annotation in SPMS show G-protein coupled receptor signaling pathway andextracellular matrix organization and etc.Conclusion: This essay demonstrated that BP۱ and SPL۱ play crucial role in mortality of SPMS. positiveregulation of gene expression and protein phosphorylation have limited in case of PPMS.