The Role of CD۸۱ Gene in the Expression of Tumor-Suppressive miR-let-۷ in HCV-Infected Patients with Hepatocellular Carcinoma

Hepatocellular carcinoma is the most frequent type of cancer in the world, and it is intimately associated toadvanced liver disease. Given the importance of hepatocellular carcinoma, there is a growing interest instudying CD۸۱ function in hepatocytes. Several members of tetraspanin superfamily have been described asmanaging different virus infectious phases at different stages, including viral entry, viral replication, virionexit, and infectivity which is associated with immunodeficiency disease, including hepatitis C (HCV) whichis a serious human pathogen with a high chronicity rate [۳,۴]. Chronic hepatitis C (CHC) is a virus that causeshepatocellular cancer (HCC) in people. The family of miR-let-۷, a kind of short non-coding RNA thatregulates the expression of certain genes, contains ۱۲ members of miRNAs. Some of them have demonstrateddysregulation results in the less differentiated cellular phase and development of cell-based disorders likecancer. In this study, the roles of CD۸۱ gene and miR-let-۷ were discussed in promotion of hepatocellularcarcinoma in HCV-infected patients to validate the related prior reports. The function of CD۸۱ gene wasinvestigated through GeneCards and KEGG databases. MiRWalk and miRBase databases showed theinvolved members of miR-let-۷ family in HCC and related to CD۸۱ gene. According to the bioinformaticsanalysis, CD۸۱ plays a role in HCV infection, which may lead to the development of HCC by interactionwith miR-let-۷ downregulation. It is concluded that considering level of miR-let-۷ expression may suppresscell line proliferation in HCC. Overall, it seems reasonable to assume that CD۸۱ is associated with HCV andHCC.

Keywords:

HCC , HCV , CHC , miRNA , Bioinformatics