Diet Therapeutics Interventions for Obesity: A Systematic Review and Network Meta-Analysis

Background: Up to now, different diet therapeutics interventions have been introduced for thetreatment of obesity. The present study aimed to compare the diet therapeutics interventions forobesity simultaneously.Study design: Systematic review and network meta-analysisMethods: The major international databases, including Medline (via PubMed), Web of Science,Scopus, Cochrane Library, and Embase, were searched using a predesigned search strategy.Randomized controlled trials (RCTs) that had compared the diet therapy interventions wereincluded. The mean difference with a ۹۵% confidence interval was used to summarize the effectsize in the network meta-analysis. The frequentist approach was used for data analysis.Results: In total, ۳۶ RCTs out of ۹۳۳۵ retrieved references met the inclusion criteria in this review.The included RCTs formed nine independent networks. Based on the results,Hypocaloricdiet+Monoselect Camellia (MonCam, P=۰.۹۹), energy restriction, behaviormodification+exercise (LED) (P=۰.۹۹), sweetener at ۲۰% of total calories (HFCS۲۰)+Ex (P=۰.۶۷),catechin-richgreentea(۶۵۰)+inulin (P=۰.۶۸), very low calorie diet (VLCD) (P=۱.۰۰), normal proteindiet+resistance exercise (NPD+RT) (P=۰.۸۰), low-calorie diets+exercise (Hyc+Ex) (P=۰.۸۵), highsoy-protein low-fat diet (SD) (P=۰.۷۵), calorie restriction+behavioral weight loss (Hyc+BWL)(P=۰.۹۹) were the better treatments for weight loss in the networks one to nine, respectively.Conclusion: Based on the results of network meta-analysis, it seems thatHypocaloricdiet+MonCam, LED, HFCS۲۰+Ex, catechin-rich green tea +inulin, VLCD, NPD+RT,Hyc+Ex, SD, Hyc+BWL, are the better treatments for weight loss in patients with overweight andobesity.

Keywords:

Diet therapy , Network meta-analysis , Obesity