An efficient approach one-pot three-component synthesis of pyrimido[۲,۱-b][۱,۳]oxazine derivatives via reaction of dialkyl acetylenedicarboxylates with isocyanide derivatives in the presence of ۶-methyl-۵-nitrouracil
Publish Year: 1401
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
CHCONFE04_005
تاریخ نمایه سازی: 20 بهمن 1401
Abstract:
The reaction of isocyanide derivatives with dialkyl acetylenedicarboxylates in the presence of ۶-methyl-۵-nitrouracil to
proceeded smoothly at room temperature and under mild conditions to afford synthesis of dialkyl-۲-(alkylamino)-۶-
methyl-۷-nitro-۸-oxo-۴H,۸H-pyrimido[۲,۱-b][۱,۳]oxazine-۳,۴-dicarboxylate derivatives in excellent yields. All products
were established by IR, ۱HNMR, ۱۳CNMR, Mass spectroscopy and elemental analysis
Authors
Milad Bazaz Rastkar
Department of Chemistry, Karaj Branch, Islamic Azad University, Karaj, Iran