A Versatile and Efficient Deep Eutectic Solvent for One-pot four-component synthesis of polyhydroquinolines

An efficient three-component reaction of aromatic aromatic aldehyde, ۱,۳- cyclohexanedione/dimedone, and ethyl acetoacetate and ammonium acetate have been developed as an atom-economic procedure catalyzed by a deep eutectic solvent [Urea][SnCl۲]۲. Conversion was high under optimal conditions. Other remarkable features include a much milder procedure, a shorter reaction time, a wide range of functional group tolerance, and absence of any tedious workup or purification. This procedure also avoids volatile organic and hazardous reagents/solvents and is thus an eco-friendly alternative to the existing methods.

Keywords:

Deep Eutectic Solvent , Multicomponent reaction , polyhydroquinolines , reusable.