The Effect of Silver Nanoparticles Produced from Extract of Medicinal Plant (Kelussia) on Kidney Function Tests

Background & Objectives: Kelussia odoratissima is involved in the treatment of kidney stones, irritation of the urinary tract and kidney and bladder cleansing. It is useful for gout patients and is used to treat kidney and ureteral stones. The aim of this study was to investigate the effect of Kelussia odoratissima on renal function tests in male rats. Materials & Methods: In this study, ۲۰ rats were randomly divided into one control group and three treatment groups (n=۵ per group). The treatment groups received a ۴۰, ۸۰, and ۱۲۰ mg/kg silver nanoparticles produced by the extracts of Kelussia, orally once a day for ۶ days. After taking a blood sample, a kidney function test was performed. SPSS software version ۲۱ was used for data collection, and the results were presented as mean and standard deviation (mean±SEM). Results: Oral administration of silver nanoparticles produced by Kelussia extracts at ۸۰ mg/kg dose significantly reduced bilirubin and urea compared to the control group (P<۰.۰۵). The ۱۲۰ mg/kg dose also significantly reduced urea compared to the control group (P<۰.۰۵). There was no significant effect on total protein, albumin and urea. Conclusion: Silver nanoparticles produced by the Kelussia extracts did not show any negative effect on kidney function, but had some positive effect on waste removal.

Keywords:

Kelussia , Kidney , Rat