Anti colon cancer efficacy of Ferula assa-foetida in modulating the detoxification enzymes and β-catenin
Publish place: The First International Iran Food Industry Congress
Publish Year: 1394
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
FIFIC01_054
تاریخ نمایه سازی: 9 مرداد 1395
Abstract:
The present study was undertaken to investigate the chemotherapeutic activity of Ferula (F.) assa-foetida hydroalcoholic extract on colon cancer induced by 1,2 dimethylhydrazine (DMH) in rat. Rats were classified into 4 groups: a control group without DMH; a group with injected DMH and two groups receiving F. assa-foedita extracts after DMH injection as chemotherapeutic groups. The effects of the extracts were tested by estimating the detoxification enzymes (GST & CYP 450). In following, the colon tissues were collected for colonic β-catenin assessment and histopathological analysis. The results showed that the treatment of cancer group with F. assa-foedita indicated a significant decrease in the expression levels of β-catenin and CYP450 together with the elevation of GSTs (activity and protein). These data are in parallel with decreased ACF formations in histopathological biopsies in F. assa-foedita extract treated groups. Thus, the results obtained from the present study suggested the F. assa-foedita extracts as an effective chemotherapeutic agent on colon carcinogenesis induced by DMH.
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Authors
Abolfazl dadkhah
Department of Medicine, Faculty of Medicine, Qom Branch, Islamic Azad University, Qom, I.R. Iran
faezeh fatemi
Nuclear Fuel Cycle Research School, Nuclear Science and Technology Research Institute, Tehran, I.R. Iran
salome dini
Young Researchers and Elite Club, Karaj Branch, Islamic Azad University, Karaj, Iran
fatemeh torabi
Department of physiology, Faculty of Science, Qom Branch, Islamic Azad University, Qom, I.R. Iran
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