A highly efficient synthesis of biologically active spirooxindole derivatives with MoO3 as a mild catalyst under solvent-free conditions

MoO3 as an environmentally benign nature catalyst for the multi-component efficient synthesis of biologically spirooxindole derivatives is studied. And we studied three-component, one-pot condensation of isatin/acenaphthequinone, malononitrile and different reagents including 1, 3-dicrbonyl compounds, naphthol and 4-hydroxycumarin under thermal and solvent-free conditions in the presence of MoO3 as a mild catalyst. solvent-free conditions, short reaction times, good yields, non-toxic, in expensive, simple operational procedures, one-pot, mild, easily separated from the reaction mixture with no column chromatographic separation for the economical synthesis of these fused biologically compounds are the major advantages of this literature.

Keywords:

MoO3 , Spirooxindole derivatives , Multi-component reactions , Solvent-free conditions