Evaluation of Effectiveness of Honey-Based Alginate Hydrogel on Wound Healing in Rat Model
Publish place: Journal of Applied Biotechnology Reports، Vol: 2، Issue: 3
Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JABR-2-3_004
تاریخ نمایه سازی: 29 آذر 1395
Abstract:
Alginate hydrogel and honey have a notably effect on wound healing process, therefore assessment of combined impact of those are essential. In this study, theeffect of honey-based alginate hydrogel, alginate hydrogel and commercial alginate dressings in recovery of wound in a rat model was studied. In this study, 20Wistar rats were divided into four groups of five. One wound of 1×1 cm square was marked using a template and the skin, on either side of the vertebral column betweenthe ears, excised. One of the rats in each group was euthanized on the 4th, 7th, 14th, and 21th days and skin samples were taken for histopathological analysis. Findings showed that the average total time of wound healing in group of treatedwith honey-based alginate hydrogel dressing was the best treatment as opposed to the other groups. With respect to all information obtained of the study we foundthat the honey-based alginate hydrogel is much convenient for wound dressing and treatment of surface wounds. Therefore, outcomes of the treatment make our dressinghighly promising as an alternative wound healing system for the treatment of wounds and certainly opening new path for future research and development
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Authors
Saeed Nazeri
Applied Biotechnology Research Center,Baqiyatallah University of Medical Sciences, Tehran, Iran
Esmat Mirabzadeh Ardakani
Biotechnology Research Center (BRC), Pasteur Institute of Iran, Tehran, Iran
Hamid Babavalian
Applied Biotechnology Research Center,Baqiyatallah University of Medical Sciences, Tehran, Iran
Ali Mohammad Latifi
Applied Biotechnology Research Center,Baqiyatallah University of Medical Sciences, Tehran, Iran