Glucose: an efficient catalyst for one-pot multi-component synthesis of bis(pyrazol-5-ols) in an environmentally benign manner

The biologically important bis(pyrazol-5-ols) synthesized by an efficient and convenient approach for one-pot, pseudo five-component coupling of hydrazine monohydrate, ethyl acetoacetate and aldehydes in the presence of a catalytic amount of glucose as an efficient, inexpensive and environmental friendliness catalyst. The merits of this reaction are higher product yields in shorter reaction time and environmentally benign reaction conditions.

Keywords:

pyrazol , one-pot , pseudo five-component , glucose