Computational Simulation of Neuronal Cell Response under Blast Loading With Considering Negative Pressure Phase in the Blast Load

Traumatic brain injury states to brain damage causing fromsudden trauma. This is very important to understand themechanism and effects of such damages to the brain towardthe treatment for injuries. Change in membranepermeability and membrane disruption might be the earliestcell response to a blast load. A computational frameworkfor considering the response of neuronal cell was presented.The negative pressure phase was also considered in blastload. Finite elements method with fluid-structureinteractions were used in the simulation. Cell constituentswere assumed to follow viscohyperelastic mechanicalbehavior. The Hugoniot/Mie-Gruneisen equation of statewas used for propagation of shock waves in the water. Theresults showed that the peak overpressure and duration ofthe positive phase of blast loads play an important role incell response. Finally, the results could be effective in thepotential treatments after traumatic brain injury and alsodiagnosis of brain damages.