Study on The Effectiveness of the Hydroalcoholic Extract of Artemisia Herba Alba on Blood Glucose, Body Weight, Testis Weight And Testicular Volume Variations of Type I Diabetic Rats Using Streptozotocin

Introduction: Artemisia Herba Alba has always been given attention in traditional medicine due to its therapeutic properties. It has been used to cure diseases such as diabetes. Diabetes causesdysfunction in spermatogenesis, damages testicular tissue and causes infertility. Goal: studying the therapeutic properties of the hydroalcoholic extract of Artemisia Herba Alba on blood glucose, body weight, testis weight and testicular volume variations of type I diabetic rats using streptozotocinStudy Method: forty male Wistar rats with the approximate weight of 180-250 gr were randomly selected. Then they were distributed into 5 groups including a control group and 4 groups of 8 diabetic rats who received 55 mg/kg streptozotocin. Therapeutic groups received 200 and 300 mg/kg and streptozotocin group received water and animal feed using gavage. The level of blood glucose, testis weight and testicular volume were analyzed 56 days after developing diabetes in the groups under treatment.Research Findings: oral treatment of the extract of Artemisia Herba Alba (300 mg/kg of body weight) for 56 days, significantly decreased the glucose level and significantly increased body weight and improved testicular volume in the groups under treatment. Conclusion: the results of the present research showed that Artemisia Herba Alba has ahypoglycemic effect on diabetic animals, reduces the side effects of spermatogenesis caused by diabetes and is effective in preventing the destruction of testicular tissue in rats. So it should be considered for therapeutic purposes. Alba, hypoglycemic, spermatogenesis, rat

Keywords:

Artemisia Herba Alba , Hypoglycemic , Spermatogenesis , Rat