Curcumin as an Environmental Potent Antioxidant Decreases Risk of Arthrosclerosis

Background & Aims of the Study: Oxidative stress increases platelet-derived growth factor(PDGF) gene expression in endothelial cells that contributes to vascular dysfunction andatherosclerosis. Oxidative stress generates by dys-regulated redox balance between ROSproducing systems and antioxidant systems. Also, Curcumin (Cur) as a main part of turmeric hasanti- inflammatory, antioxidant, anticancer and antitumor effects. This study was conducted totest the Curcumin as an environmental potent antioxidant decreases risk of arthrosclerosis.Materials and Methods: This experimental study was conducted during 2015 in Iran. Culturedbovine aortic endothelial cells were incubated with hydrogen peroxide (H2O2) (20, 40 and 80μM) and Curcumin (10 μM) for 24h. Then, the level of PDGF gene expression was analyzed byReal-Time PCR in untreated and treated cells.Results: The results demonstrated significant increase in the level of PDGF gene expression inH2O2 treated groups versus control. Also, treated groups with H2O2 -Curcumin showed notabledecrease in the level of PDGF gene expression compared with H2O2 treated groups.Conclusion: Our results support valuable data about the application of Curcumin for protectionagainst atherosclerosis.