Salicylic acid derivatives of epoxide for efficient synthesis of β- hydroxyl esters

Plants are a rich source of natural medicines. Indeed, people often fail to realize that many currently used drugs, including digitalis, quinine, taxol, the opiates codeine andmorphine, and aspirin [a synthetic derivative of salicylic acid (SA)] are derived from plants. Salicylic acid is a kind of β-Hydroxy acid [1, 2]. This acid is crystalline and also non colored natures and also named as ortho hydroxyl benzoate acid. In over all, Salicylic acid is an herbal internal secretion the faunded in the plants and has important roles in:growth, photosynthesis, Tran’s piration, absorpation and transfer of the materials, in view of saurce. The drugs divide to: natural, partly artificial and artificial. In order toproduction of the new partly artificial drugs. The accurate and valid changes should make on the composition of the natural material, and then, the result of this changes,could be considered [3]. In this study the reaction of Salicylic acid derivatives with the proper epoxid in the presence of Tetra butyl ammonium bromid (TBAB) in refluxing anhydrous Acetonitrile furnished β- hydroxyl esters of Salicylic acid derivatives (Scheme 1). The crud products were purified using column choromatography with proper solvent. The structure of synthesized compounds was confermed using 1H-NMR, 13C-NMR and IR spectroscopy