One-pot multicomponent synthesis of benzodiazepine derivatives

Asymmetric multicomponent reactions (AMCRs) are chemical reactions in which three or more reactants produce products that they have some advantages containing simplicity of operation, high yields, easy purification1. Heterocycles containing benzodiazepine are a class of psychoactive drugs because of their biological activities related to the central nervous system2,3.Herein, we report the synthesis of rigid seven-membered chiral heterocycles (benzodiazepines) from the reaction of cyclohexane 1,3-dione, 1,2-phenylenediamines, aldehyde derivatives in ethanol with L-proline at 80 °C.

Keywords:

Asymmetric multicomponent reactions , benzodiazepines , cyclohexane 1 , 3-dione , 1 , 2-phenylenediamines.