Synthesis of fused N-hetrocycle compounds as biologically drug candidates by using novel Zr-based MOFs with sulfonic acid tags
Publish place: 27th Iranian Seminar on Organic Chemistry
Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
ISOC27_186
تاریخ نمایه سازی: 19 اسفند 1399
Abstract:
Polyfunctionally substituted nitriles are versatile reagents that have been extensively utilized as precursors for synthesis of functionalized heteroaromatic compounds.1 Development of the synthetic routes for these compounds is a great demand.2 2-Aminoprop-1-ene-1,1,3-tricarbonitrile (1) has proved to be an excellent precursor to condensed pyridines, pyridazines, and pyrazoles.3 Herein, we wish to report novel Zr-based metal organic frameworks (MOFs) with sulfonic acid tags as a nonporous catalyst. 6-Amino-2-(dicyanomethylene)-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitriles were prepared by reaction of 2-aminoprop-1-ene-1,1,3-tricarbonitrile (1), aldehyde and malononitrile in the presence of Zr-MOFs-SO3H at 110 ◦C in excellent yields and short reaction times (Fig 1).
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Authors
Amir Mohammad Naseri,
Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali-Sina University, Hamedan, ۶۵۱۷۸۳۸۶۸۳, Iran
Mahmoud Zarei
Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali-Sina University, Hamedan, ۶۵۱۷۸۳۸۶۸۳, Iran
Hassan Sepehrmansourie,
Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali-Sina University, Hamedan, ۶۵۱۷۸۳۸۶۸۳, Iran
Mohammad Ali Zolfigol
Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali-Sina University, Hamedan, ۶۵۱۷۸۳۸۶۸۳, Iran