Synthesis of a novel magnetic nanoparticles with morpholine tags: Its catalytic application in the synthesis of 4,6-diarylpyrimidin-2(1H)-ones

Diarylpyrymidin-2(1H)-one (DAPM) belongs to one of the important class of heterocyclic compounds. DAPMs had been shown that a wide range of biological, medicinal, and therapeutic activities, such as: non-peptide antagonists, antiproliferative, cytodifferentiating activities and antihistaminic agents. On the other hands, semiheterogeneous catalysts such as magnetic nanocatalysts, present large surface-to-volume ratio which is a great solution to boost activity of a typical catalyst 1-3.In this regard, we investigated the design, synthesis, characterization and catalytic performance of a novel magnetic nanoparticle with morpholine tags at the synthesis of biological active DAPM derivatives (Scheme 1).

Keywords:

Multicomponent reactions , Diarylpyrimidine , Magnetic nanoparticle , Morpholine