A novel magnetic nanoparticle with morpholine tags as a multi-rule catalyst for synthesis of bis-dihydroquinazolinones

In recent times, synthesis of dihydroquinazolin derivatives has attracted considerable attention from organic and medicinal chemists. Dihydroquinazolin derivatives showed a wide range of pharmacological and therapeutic properties such as antimalarial, antitumor, anticonvulsant, anti-inflammatory, and antimicrobial activities. Professional chemists are seeking catalytic systems which embrace "catalyst activity" and "catalyst separation together. Nowadays, by using magnetic nanoparticles, chemists can design and apply easy separable catalysts with high activity 1-3In this presentation, we will report the one-pot synthesis of bis-dihydroquinazolinone in the presence of a catalytic amount of magnetic nanoparticles with morpholine tags as a multi-rule catalyst (Scheme 1).

Keywords:

Multicomponent reactions , Bis-dihydroquinazolinone , Magnetic nanoparticle , Morpholine.