A review on the effects of the herbal active molecules, pectins and flavonoids on the mammary gland epithelial cells and cancer cell; targeting these cell in cancer cells

Human History always was related to the use of herbal medicine which was the main treatment of diseases.Chemical drugs applying became popular along with developing science and industry. As such drugs contained side effects, using herbal medicine resume. There are two kinds of herbal effective substances: the first one is the primary metabolic substances such as polysaccharides (pectins). The other is the secondary metabolic substances as flavonoids. We assessed the effects of these herbal effective molecules on cancerous and healthy cells. The polysaccharides (pectins) were studied on GH۳/B۶ cells which are capable of secret Prolactin and Growth Hormone. The datawere shown the effect of pectins on these cells. In the second group, we studied the flavonoid named Salvigenin. In cancer cells, Salvigenin could link to P۵۳ following cycling-CDK linkage to inhibit the cell cycle in G,M and S phase. In such conditions, P۵۳ plays an apoptotic role while it plays an anti-apoptotic role in normal cells. Our results declared that salvigenin accompany magnetic nano-particles promoted the apoptotic effects of this molecule alone. It is worth mentioning that such effects were not seen in normal cells. The PLGA synthetic polymer with sedimentation method used to prepare Fe۳O۳@mPEG-b-PLGA.