Study on Gelatin/Ag Nanofiber for biomedical Application

A series of new and commercially available polymers have been proposed as matrices for cell regeneration and proliferation for tissue engineering applications but lot of questions like interaction of scaffolds with biological systems, toxicity, in vivo studies etc. In this Study Gelatin/Ag nanofibers were prepared via electrospinning using aqueous solutions of acetic acid/water as the solvent instead of cylotoxic solvents. The parameters, such as electric field, concentration of solutions and spinning distance were examined for studying the effects on spinability and morphology of gelatin nanofibers mats. The lowest diameter of gelatin nanofibers was achieved when the gelatin concentration was 10%. Morphology of nanofibres was examined by scanning electron microscopy and diameter distribution and uniformity were measured with image analyzer software. The antibacterial activities of nano silver in nanofibers were calculated by percent reduction of Staphylococcus aurous. The results showed that the spinability of gelatin strongly depend on the solvent used. The results of antibacterial test indicated excellent antibacterial effect on all specimens against S. aurous.

Keywords:

Gelatin , Ag , Nanofiber , Electrospinning , Biomedical , Wound dressing