Solubility Correlation of Three Drugs in Supercritical Carbon Dioxide with Empirical Models and A New Empirical Model

Collected solubility data of Clozapine, Lamotrigine, and Cetirizine are correlated using a new proposed empirical model, and the accuracy of the model prediction is compared to some commonempirical models in the literature. all studied models show good agreement between predicted andexperimental data. In this study, it’s assumed that all collected data are accurate.according to obtained result, the new empirical model gives better prediction result, as well as, it’s more reliable. So it can be employed in the future data correlations.

Keywords:

Supercritical fluids , drug solubility , modeling , correlation , empirical models