The Impact of Liraglutide on the Urogenital and Reproductive System in Mice

Introduction: We aimed to evaluate whether Liraglutide can remove the deteriorating impact of a high-fat diet (HF) diet on the genitourinary system.Methods: Fifty-six C۵۷ mice were recruited of which received an HF as the intervention group, and a chow diet (CH) as a control group. After two months the case group was sub-grouped into three groups; ۱: group HF with a daily injection of ۰.۴mg/kg liraglutide (HF+Lir), ۲: CH with a daily injection of ۰.۴mg/kg liraglutide (CH+Lir), and ۳:  HF diet with an infusion of normal saline (HF+NS). After two months, all mice were sacrificed for additional testing.Results: Serological analysis showed no significant difference for lipid profile (P-value>۰.۰۵) and hormones except for PSA in males (P-value=۰.۰۱۹). This significance was seen when comparing CH+Lir and HF+NS to the control group (P-values=۰.۰۱۴ and ۰.۰۲۵, respectively). Liraglutide decreases testosterone in both genders and adiponectin and insulin in males. Total sperm count was decreased, and the difference between the groups was significant (P-value=۰.۰۱۳).Conclusions: Liraglutide cannot recover the deteriorating impact of an HF diet on sperm morphology and motility but can improve the sperm DFI and the total number of sperm.

Keywords:

Liraglutide , Urogenital System , Reproductive system , sperm count