Therapeutic Potential of Glucose Regulated Protein 78 in Cancer
Publish place: Journal of Applied Biotechnology Reports، Vol: 2، Issue: 4
Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
View: 635
This Paper With 6 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
این Paper در بخشهای موضوعی زیر دسته بندی شده است:
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_JABR-2-4_003
تاریخ نمایه سازی: 29 آذر 1395
Abstract:
Endoplasmic reticulum has a critical role in the synthesis and folding of secretory and membrane proteins. High accumulation of proteins in ER activates the unfoldedprotein response and glucose regulated protein 78 or GPR78 plays an essential role in this pathway. Unfolded protein response is activated in cancerous cellsdue to their adverse condition to survive and it has been shown that GRP78 can be expressed in tumor cell membrane. Overexpresion and localization of GRP78makes it a suitable target for the treatment of cancer. This review describes cellular localization, biological function, and role of GRP78 in cancer induction. Methods for tumor inhibition via GRP78 are also discussed.
Keywords:
Authors
Hosssein Aghamollaei
Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Seyed Latif Mousavi Gargari
Department of Biology, Faculty of Basic Science, Shahed University, Tehran Iran
Mostafa Ghanei
Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran