[60]Fullerene-based Pt(0) complexes of phosphorus ylide, Efficient Nanodrugs as new anticancer agents

In the past two decade, there has been considerable interest in the synthesis, structure, and properties of the transition metals compounds, in which the C60 cage is attached to organometallic groups to form corresponding π-complexes [1]. This work reports the synthesis and catalytic properties of new bidentate platin(0)[60] fullerene complexes, prepared by reaction of α-keto stabilized phosphorus ylides [P2R4=C(H)C(O)C6H4-p-R] (R = OMe, NO2 (Y1, Y2)), C60 and Pt2(dba)3 (dibenzylideneacetone (dba)). The observed coordination mode is orthometalate P,C-coordinated in the case of [(η2−C60)Pt(κ2 −Y1)] (1) and [(η2−C60)Pt(κ2−Y2)] (2) complexes [2]. All complexes have been fully characterized by 1H, 13C and 31P NMR spectroscopic methods and other conventional techniques such as IR, thermogravimetry and scanning electron microscopy. Additionally, the current study presents evidence that the investigated compounds induce the anti-proliferative effect in the human gastric (AGS), breast (MCF-7), and lung (A549) cancer cells. Our data indicated that the compounds have excellent anticancer due to Pt nature and ligand properties. It should be noted that although all in vitro experiments hold limitations with respects to possible in vivo efficiency, the results are very promising with regards to possible antineoplastic chemotherapy and form a very sound basis for future research.