Perovskite/GO nanosheets for determination ofpiroxicam in biological and drug samples

Piroxicam is a drug from the oxicam family and is an anti-inflammatory drug. This drugis used to relieve pain in humans. For the reasons mentioned, piroxicam becomes importantto measure. One of the best ways to measure the piroxicam is using sensing assays. In thisresearch, the modifiers are perovskite nanosheets and graphene oxide (GO). The morphologyof La(Fe۰.۷Mn۰.۳)۰.۹Pd۰.۱O۳, GO, and La(Fe۰.۷Mn۰.۳)۰.۹Pd۰.۱O۳/GO nanocomposite wereexamined by SEM, EDX, FT-IR, XPS, XRD analysis. CV and DPV techniques were used toinvestigate the electrochemical behavior of piroxicam and quantification, respectively. Theabove-mentioned electrode has been utilized to determination the piroxicam. LOD was ۰.۸۹μM and a linear range of ۶ μM -۱۰۳ μM was obtained for thepiroxicam oxidation process.Eventually, the designed analytical method was used for detection and quantification ofpiroxicam in capsule and human plasma samples. The obtained results from the designedsensor specify adequate analytical characteristics consisting low LOD, widespread linearrange, and acceptable proficiency for the highly sensitive recognition of piroxicam. Additionally,La (Fe۰.۷Mn۰.۳)۰.۹Pd۰.۱O۳/GO GCE showed acceptable stability, repeatability, andreproducibility. Furthermore, to investigate the accuracy of the mentioned assay, the recoveryindex of ۹۶.۴۱% (RSD< ۵%) indicates high performance in real samples.

Keywords:

Sensor , Perovskite , Nanocomposite , Graphene oxide , Human plasma